PDE5 inhibitors duration — what to expect from sildenafil, tadalafil, vardenafil and avanafil

Wondering how long a PDE5 inhibitor will work? Knowing the typical onset and how long effects last helps you plan timing, avoid surprises, and pick the right medicine. Below I cover common drugs, realistic windows for effect, and practical safety pointers.

How long each drug usually lasts

Sildenafil (Viagra) usually starts working in 30–60 minutes and keeps working for about 4–6 hours. High-fat meals slow absorption, so take it on a lighter stomach if you want a faster start. The most common side effects are headache, flushing, and occasional vision changes.

Tadalafil (Cialis) can be the easiest to plan around: it often kicks in by 30 minutes and can last 24–36 hours. That doesn’t mean you’re constantly erect — it means you have a longer window where sexual activity can trigger an erection. Tadalafil also has a daily low-dose option for people who prefer spontaneity.

Vardenafil (Levitra) behaves a lot like sildenafil: onset at about 30–60 minutes and duration around 4–6 hours. It’s a good option when sildenafil didn’t suit you, though side effects are similar. Avanafil (Stendra) is the fastest acting: some people notice effects in 15–30 minutes, with benefits that last roughly 4–6 hours.

Practical tips and safety you can use right away

Timing matters: take sildenafil or vardenafil about an hour before sex; avanafil about 15–30 minutes; tadalafil can be taken earlier or daily for regular use. Avoid heavy, fatty meals with sildenafil and vardenafil — they delay how fast the drug works. If you drink alcohol, keep it moderate; lots of booze can blunt the response.

Watch interactions: never take any PDE5 inhibitor with nitrates (used for chest pain). Combining them can dangerously lower blood pressure. Also be cautious with strong CYP3A4 inhibitors like ritonavir or certain antifungals; they raise PDE5 levels and may boost side effects.

If one drug or dose doesn’t work, don’t give up after one try. Talk to your clinician about dose adjustments, switching drugs, or checking for underlying causes like diabetes, low testosterone, or circulation problems. Seek urgent care if an erection lasts more than 4 hours (priapism) or if you feel dizzy or faint after dosing.

Short summary: sildenafil and vardenafil = ~4–6 hours, avanafil = fast onset and ~4–6 hours, tadalafil = long window up to 36 hours. Use the timing tips above and talk with your doctor about interactions and the right choice for your life and health.