Compare Erectile Dysfunction Meds: Sildenafil, Tadalafil, Vardenafil & More

When you're looking for help with erectile dysfunction meds, oral medications that improve blood flow to support erections by blocking PDE5 enzymes. Also known as PDE5 inhibitors, they're the most common first-line treatment for ED, used by millions worldwide. But not all of them are the same. Some kick in fast but fade quick. Others last longer but take more time to start working. Choosing the right one isn't just about price—it's about how your body responds, what you need it to do, and how it fits your lifestyle.

Take sildenafil, the active ingredient in Viagra and many generic versions, known for rapid onset and reliable results. It usually works in 30 to 60 minutes and lasts about 4 to 5 hours. Then there's tadalafil, found in Cialis and Tadarise, which can last up to 36 hours and lets you be spontaneous without timing doses around sex. vardenafil, the active ingredient in Levitra and Fildena Professional, works similarly to sildenafil but may be more effective for men with diabetes or after prostate surgery. Each has different side effect profiles—headaches, flushing, or upset stomach are common, but some men report fewer issues with one over another. Dosing also varies: sildenafil is often taken at 50mg, tadalafil at 10mg or 20mg, and vardenafil at 10mg, but your doctor might adjust based on your health or other meds you're on.

What you’ll find below is a real-world breakdown of how these pills stack up against each other. No fluff. No marketing spin. Just direct comparisons from posts that look at Malegra FXT, Fildena Professional, Tadarise, Viagra alternatives, and more. You’ll see how onset times, duration, cost, and even combo formulas (like sildenafil with fluoxetine) affect results. Some men need a pill that works fast for planned intimacy. Others want something that stays ready all weekend. There’s no one-size-fits-all answer, but the data here will help you cut through the noise and find what actually works for you.